If you are looking to change the opt out status of prospects in PersistIQ, you can do so in the advanced settings upon importing a list of prospects.

When you are trying to upload another list of prospects to PersistIQ duplicates will be detected and won't be added twice to the master prospects list. However, if you would like to have all of the prospects in your import you can easily go to the advanced settings and choose to update the duplicates.

Access the advanced settings as visible in the following video to choose to update the duplicates, then mark prospects from the import as "Opted out";